Protein mutation seen as ke to Crohn's disease Crohn's disease is a dabilitating condition, and
now scientists have found some genetic information that is
providing some insight into the causes of Crohn's. If there is a
mutatiion (abnormality) on one of the chromosomes (part of human
DNA) #16, then the chances of developing Crohn's are increased by
25%. Previously, scientists knew that family history played a part
in Crohn's development, but it was unknown why. The protein that is
affected, Nod2, is involved in starting the immune system response,
so if the Nod2 was restored, then people with a susceptibility to
Crohn's could be helped from developing it. Scientists say that
there are probably a number of mutations that are responsible for
the development of Crohn's, but the important factor is how they
all interact.. MAY 22, 2001
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